The Health Risks of Extraterrestrial Environments
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Archive


NASA Space Radiation Summer School
Overview
2004
2005
2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017

30th Space Radiation Investigators' Workshop (2019)
29th Space Radiation Investigators' Workshop (2018)
28th Space Radiation Investigators' Workshop (2017)
27th Space Radiation Investigators' Workshop (2016)
26th Space Radiation Investigators' Workshop (2015)

Under construction

Cancer Risk I Sessions
Cancer Risk II Sessions
Cancer NSCOR I Sessions
Cancer NSCOR II Sessions
The Radiation Carcinogenesis Specialized Center of Research
Emory NSCOR Overview Progress
Characterization of the Tumor Sepctrum Arising in HZE Ion Irradiated Outbred Mice
In Vivo Induction of Aberrant Patterns of DNA Methylation and Chromosome Instability in Hematpoietic Stem/progenitor Cells (HSPCs) by Silicon (28Si) Ions
Functional Role of BCL2 in Regulating the Repair of the HZE Particle-Induced DNA Damage
mBand Analysis of Late Chromosome Aberrations in Human Lymphocytes Induced by Low- and High-LET Radiation
Update of Harderian Gland Tumorigenesis: Low-Dose- and LET-Response
Micronucleus Formation in Human Skin Kerationcytes Exposed to Different Radiation Qualities in 2D and in 3D
Exposure to 56 Radiation Induces Persistently Increased Serum Levels of Known Colorectal Cancer Biomarkers in C67BL/6J Mice
Long-term Differential Changes in Mouse Intestinal Metabolomics after γ and Heavy Ion Radiation Exposure
The Contribution of Non-Targeted Effects in HZE Cancer Risk
Smad7 Foci Present in Micronuclei Induced by Heavy Particle Radiation
Development of a Risk Assessment Model for Lung Cancer Pathogenesis After Exposure of Human and Mouse Lung Epithelial Cells to HZE Particle Radiation
Biological Countermeasures of Space Radiation-induced Invasive Carcinomas in Mouse Models of Lung and Colon Cancer
Duke NSCOR: Lung Cancer Risk from HZE Ions


Poster Session I
Poster Session II
Fractionated Protons and HZE Radiation to Rat Spinal Cords Increases Base Exicision Repair, Induces Demyelination, Neuro-Inflammation in Brain, Cognitive Deficits and Non-Targeted Tumor Induction
Persistent Changes in Neuronal Structure and Synaptic Plasticity Caused by Proton Irradiation
Deletions of Ink4, Arf, p53, or Pten Cooperate with HZE Particle-Induced DNA Double-Strand Breaks to Trigger High Grade Gliomas in Mouse Models
Using EUD4TEA as the Active Element for Space-Based Radiation Sensors
Development of Cognitive Performance Decrements as a Function of Time Following Exposure to HZE Particles
Induction of Radiation Signature Mutations In Vivo with Charged Particles at Low Fluence
Space Radiation Induced Neuroinflammation on Alzheimer and Parkinson Disease Pathology
Suppression of Genome Instability in Response to Space Radiation is Mediated by Fanconi Anemia Pathway
Low Dose Space Radiation Affects Long-Term Survival of Bone Marrow Progenitor Cell Populations
Effects of Combined Proton and 56Fe Irradiation on Hippocampal Function
Inflammatory Responses and Aberrant Patterns of DNA Methylation in the Liver of Mice Exposed Whole-Body to Titanium (48Ti) Ions
A Genomic Stress Response as a Novel Mechanism Leading to Chromosomal Instability in Heavy Particle-Irradiated Cell Populations
Applying Lessons Learned from Clinical Radiotherapy to Improve Biophysical Modeling of Clinical Outcomes Used to Guide Management and Countermeasures Following Acute Radiation Exposures
Individual Differences in Neurobehavioral Deficits Following Proton Irradiation are Related to Differential Brain Protein and Cytokine Expression
The Role of Persisting Phenotypes on Radiation-Induced Genomic Instability
Effects of 28Si Radiation on Neurobehavioral Function
Development of a New Improved Biodosimetry Method for Measuring Previous Exposure to HZE Radiation
Autosomal Mutants of Proton-Exposed Kidney Cells Display Loss of Heterozygosity on Other Chromosomes
Protons and HZE Radiation Affect Hippocampal Functions in APP/PSEN1 Transgenic Mice
Radiation Quality Effects on Transcriptome Profiles in 3-D Cultures After Charged Particle Irradiation
The Role of the Bone Marrow Microenvironment in Space Radiation-Induced Leukemogenesis
An Extra Copy of p53 Suppresses Initiation of Kras-Driven Tumors but not Radiation-Induced Lymphomas
Effects of Heavy-Ion Irradiation on Ex Vivo Osteoblastogenesis, Oxidative Stress Response, and Cancellous Bone Microarchitecture
High LET Radiation Produces Sustained DNA Damage Signaling and Changes Cellular Homeostasis in Hippocampal Neuronal Cells
Role of Age, Radiation Quality and Genetic Background on Levels of Surrogate Cancer Biomarkers
The Tumor Suppressor P53 Acts During Total-Body Irradiation to Decrease Hematopoietic Stem/Progenitor Cell Fitness and to Promote Lymphoma Development
Fractionated High LET Iron Irradiation Effects on K-RasG12D-Induced Tumor Progression
The Radioresponse of Normal Human Bronchial Epithelial Cells to Charged Particle Exposures of Increasing Mass, Energy and LET
High LET 56Fe Ion Irradiation Induces Tissue Specific Changes in DNA Methylation in the Mouse




Program
Translocator Protein 18 kDa (TSPO), a Potential In-Vivo Biomarker of Space Radiation Induced CNS Injury
Role of NADPH Oxidase in Low-Dose Radiation-Induced Neurovascular Remodeling in Mouse Hippocampus
Radiation-Induced Alterations in Synaptic Transmission of Dentate Granule Neurons Depend on the Dose and Species of Charged Particles
Effects of Space Radiation on Hippocampal-Dependent Learning and Neuropathology in Wild-Type and Alzheimer's Disease Transgenic Mice
Charged Particle Radiation, Reactive Oxygen Species, and CNS Function
Reliability of the Disruptive Effects of Exposure to Protons on Neurocognitive Performance
Charged Particle Radiation, Reactive Oxygen Species, and CNS Function
Functional Effects of Proton Radiation on Synaptic Transmission and Plasticity in the Hippocampus of APP/PSEN1 Transgenic Mice
Radiation-Induced Suppression of LTP is Associated with Altered Intrinsic Membrane Properties in Hippocampal CA1 Neurons
Fractionated Ionizing Radiation Skews Differentiation of Glial/Oligodendrocyte Progenitor Cells and Induces Cognitive Defects
Functional Effects of Proton, Silicon and Iron Radiation on Synaptic Excitability in the Mouse Hippocampus


Program
Low Doses of Proton Radiation Do Not Induce Spatial Learning or Memory Deficits in a Mouse Model of Alzheimer's Disease
Modeling Cell-Intrinsic Effects of Low vs High LET Ionizing Radiation on Lung Epithelial Progenitor Cells
The Mechanism and Treatment of Coagulopathy in Proton Irradiated Ferrets
Role of p53 in Lung Carcinogenesis After Exposure to Space Radiation
Heterozygous Deletions of p53 and PTEN Cooperate with DNA Damage Induced by Fe Ions to Trigger High Grade Gliomas in Mouse Models
Long-Term Effects of a Single Exposure of the Vertebrate Embryo to High Charge and Energy (HZE) Particle Radiation
A Systems Genetic Analysis of Susceptibility to Development of Tumors Induced by High LET Radiation
Consequences of Low-Dose HZE Irradiation in the Cortical Bone of Aged Mice
Student Poster Contest Winners





Introduction to THREE
Walter Schimmerling

Video presentation of
Research Solutions to Space Radiation Impacts on Human Exploration
Slides in PDF format
Francis A. Cucinotta, Ph.D.
Chief Scientist, Space Radiation Program
NASA Johnson Space Center
Houston, Texas
Aerospace Medicine Grand Rounds
March 23, 2010

Radiation and Human Space Exploration Video
NASA Human Research Program

Radiation tracks and radiation track simulation video
Ianik Plante, Ph.D.
Universities Space Research Association
Division of Space Life Sciences
NASA Johnson Space Center
Houston, Texas

Radiation tracks and radiation track simulation video is excerpted from the article:
Radiation chemistry and oxidative stress (PDF)
Ianik Plante, Ph.D.

Video Presentation of
Space Radiation and Cataracts
Eleanor Blakely
Life Sciences, Lawrence Berkeley National Laboratory
Berkeley, California
July 16, 2003